Lab News
August 23, 2024: Congratulations, Youqiong Ye received grant from the National Natural Science Foundation of China (Outstanding Youth Science Foundation)
August 23, 2024: Congratulations, Youqiong Ye and Yanhua Du received grant from the National Natural Science Foundation of China (General Program)
July 2, 2024: Congratulations, Zhenzhen and Mingyi's paper was published in Advanced Science. Identification of Hypoxia-ALCAMhigh Macrophage- Exhausted T Cell Axis in Tumor Microenvironment Remodeling for Immunotherapy Resistance
April 24, 2024: Congratulations, Our collaborative paper was published in Genome Medicine. Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors
April 15, 2024: Congratulations, Jintong and Weixia's paper was published in Cancer Research. The Web-Based Portal SpatialTME Integrates Histological Images with Single-Cell and Spatial Transcriptomics to Explore the Tumor Microenvironment
April 12, 2024: Congratulations, Our collaborative paper was published in Immunity. 25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
February 15, 2024: Congratulations, Our collaborative paper was published in Immunity. Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells
January 17, 2024: Congratulations, Yanhua and Jintong's paper was published in Cancer Research. Integration of pan-cancer single-cell and spatial transcriptomics reveals stromal cell features and therapeutic targets in tumor microenvironment
January 17, 2024: Congratulations, Our collaborative paper was published in BMC Medicine. Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma
November 28, 2023: Congratulations, Our collaborative paper was published in Journal for Immunotherapy of Cancer. High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy
October 19, 2023: Congratulations, our collaborative paper was published in Cell Metabolism. Article Dietary fructose-mediated adipocyte metabolism drives antitumor CD8 + T cell responses Article Dietary fructose-mediated adipocyte metabolism drives antitumor CD8 + T cell responses
April 11, 2023: Congratulations, our article titled “Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer” is in the Top 25 health sciences articles in Nature Communications from 2022.
March 18, 2023: Congratulations, Yu's paper was published in Nature Communications. Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy
January 25, 2023: Congratulations, Zhenzhen's collaborative paper was published in Journal of hepatology. Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy
January 5, 2023: Congratulations, Zhenzhen's paper was published in Nature Communications. Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis
October 28, 2022: Yu's collaborative paper is accepted to Oncogene.
September 22, 2022: our collaborative work with Dr. Dalong Ni is published in Scinece Advances. Oral zero-valent-molybdenum nanodots for inflammatory bowel disease therapy
July 22, 2022: Congratulations, Gaoyang's paper was published in Cancer Research. Characterization of immune-related alternative polyadenylation events in cancer immunotherapy
July 19, 2022: Congratulations, Jintong's collaborative paper was published in Nature Immunology. tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
May 10, 2022: Congratulations to Gaoyang Wang for passing his master’s thesis defense.
April 25, 2022: Congratulations, He's paper was published in Signal Transduction and Targeted Therapy. Multi-omics characterization and therapeutic liability of ferroptosis in melanoma
April 1, 2022: Qi's paper was published in Nature Communications. Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
March 17, 2022: Our collaborative paper was online in Cancer Research. RNA helicase DHX37 facilitates liver cancer progression by cooperating with PLRG1 to drive super enhancer-mediated transcription of cyclin D1
March 25,2022: Congratulations to Yu Dong for passing his Post-doctoral defense.
August 26, 2021: Our collaborative spotlight paper is published in Cancer Cell. ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy
October 1, 2021: Our collaborative paper is published in Journal of Clinical Investigation. ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells
August 3, 2021: Shen's review paper is accepted in Medical Review.
November 30, 2021: Ye's paper is accepted in The Innovation. Profiling of immune features to predict immunotherapy efficacy
January 22, 2021: Chen's paper is accepted in Molecular Cancer.Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer
December 14, 2020: Our collaborative paper is online in Cancer Cell. YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
November 27, 2020: Our collaborative paper is online in Advanced Science. The beneficial role of sunitinib in tumor immune surveillance by regulating tumor PD-L1.
September 10, 2020: Ye's paper is online in Genome Medicine.Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1
May 01, 2020: Ye's review paper is online in Trends Genetics. A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine
April 14, 2020: Ye's paper is online in Nature Communications. Sex-associated molecular differences for cancer immunotherapy
January 06, 2020: Ye's Lab is established in Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine.