Reseach

Our laboratory mainly focuses on tumor microenvironment and immunotherapy (http://www.yelab.site/). We take full advantage of the multi-omics data in human cancer, combine with innovative bioinformatics methods, wet experiments, and clinical cohort to investigate the roles of tumor microenvironment in tumor development, immune escape and immunotherapy, and provide novel therapeutic strategies based on tumor spatial microenvironment (Journal of Hepatology 2023; Cell Metabolism 2023; Cancer Research, 2022, 2023; Nature Communications, 2020, 2022, 2023a, 2023b; Cancer cell, 2020; Nature Metabolism, 2019; Nature Immunology, 2019; etc.).

The main research contents as follows:

1. Combining multi-scale data such as spatial transcriptomics, single-cell multi-omics, pathological images, etc., to construct approaches to accurately study the regulation roles of tumor boundary microenvironment in tumor progression, and immunotherapy resistance, and to develop new therapeutic strategies based on the targets in tumor boundary microenvironment;
   
2. Single-cell and other omics based clinical cohorts reveal tumor microenvironment-related characteristics to assist tumor immunotherapy.